Dibenamine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DibenamineHClide 是一种竞争性且不可逆的 β-肾上腺素受体阻断剂。

Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.(In Vitro):Dibenamine hydrochloride (100 nM-10 μM) attenuates the extent of cocaine-induced increases in sensitivity to acetylcholine, furthermore, the extent of diphenylamine-induced inhibition depends on the concentration of diphenylamine, which is inversely proportional to the concentration of cocaine. Dibenamine hydrochloride did not have any effect on acetylcholine contraction of isolated guinea-pig vas deferens .(In Vivo):Dibenamine hydrochloride causes a significant increase in the rate of destruction of L-epinephrine in the mouse. Pretreatment with Dibenamine hydrochloride apparently slowed the conversion of Ccl4 to CHCL3. Dibenamine hydrochloride (25 mg/kg; s.c.) decreased the CHCl3, levels at 2 and 6 hr by 30%-50%.

Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine.

Dibenamine hydrochloride (subcutaneous?injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3.

N-?(2-?Chloroethyl)?dibenzylamine hydrochloride

Angiogenesis

Adrenergic Receptor

Akt|AP-1|COX|HO-1|MAPK|NF-κB|NO|NOS|Nrf2|p65|PDGFR|PGE|ROS|TNF-α

——

——

55-43-6

296.24

C16H19Cl2N

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (421.97 mM)

Cl.ClCCN(Cc1ccccc1)Cc1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years